I typed…. hesitating before I hit ENTER. What the hell I thought – they not my friends – probably never see them in VR World again. “We could help you satisfy that” came the typed reply. I just knew it – they wanted it and now they know what I want. “I knew you would say that” I typed. I glanced up from my Laptop as I heard laughter from behind me. I swivelled round to see the two guys from the Balcony sat at the next table behind me, starring at a Laptop. “Your not in VR…” I began “We are!” I was interrupted OMG went through my mind! – I have just revealed my deepest fantasy to a couple of VR lads in Merlins, just for a laugh, and they are sat behind me in real life!! I turned back to my laptop and shut the lid – not knowing where to look or what to do – I was so embarrassed.! Fumbling with my laptop case/ mouse /wires – I desperately packed to make a quick exit. “Hey, honey wassup? We are just being friendly, and you look so alone” came a voice not so distant. I daren’t look round. The word prion is a portmanteau of the phrase ‘proteinaceous infectious particle’, and was coined by the human researcher Stanley Prusiner at that time. The existence of prions had been suspected by other researchers as early as 1962, but the concept hadn’t been named. Prusiner and others succeeded in isolating prions associated with the sheep disease ‘scrapie’ in the early 1980’s, and since that time a number of other animal and human diseases have been found to have prions as causative agents. Most notable are the spongiform encephalopathies Creutzfeldt-Jakob and kuru, found in humans, BSE (Mad Cow Disease) in cattle, and TSE (Chronic Wasting Disease) in deer and other animals.The ‘discovery’, or rather proof of existence, of prions made a new line of inquiry available to our researchers, who immediately adapted the techniques used by Prusiner and others to attempt to recover prions from a group of volunteers of our kind. These early attempts failed, for the most part, except when.
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